Sunday, March 3, 2013

AP: NY fracking held as Cuomo, RFK Jr. talk health

These 2013 file photos show New York Gov. Andrew Cuomo, left, in Albany, N.Y. and Robert F. Kennedy Jr. in Dallas, Texas. People familiar with Cuomo's thinking on fracking tell The Associated Press he was on the brink of approving the much-debated gas drilling method in February 2013 but held off after discussions with environmentalist and former brother-in-law, Kennedy. (AP Photo/Tony Gutierrez)

These 2013 file photos show New York Gov. Andrew Cuomo, left, in Albany, N.Y. and Robert F. Kennedy Jr. in Dallas, Texas. People familiar with Cuomo's thinking on fracking tell The Associated Press he was on the brink of approving the much-debated gas drilling method in February 2013 but held off after discussions with environmentalist and former brother-in-law, Kennedy. (AP Photo/Tony Gutierrez)

(AP) ? New York Gov. Andrew Cuomo came as close as he ever has to approving fracking last month, laying out a limited drilling plan for as many as 40 gas wells before changing course to await the findings of a new study after discussions with environmentalist and former brother-in-law Robert F. Kennedy Jr., several people familiar with his thinking told The Associated Press.

The turning point, which could delay a decision for up to a year or longer, came in a series of phone calls with Kennedy. The two discussed a new health study on the hydraulic fracturing drilling method that could be thorough enough to trump all others in a debate that has split New York for five years.

"I think the issue suddenly got simple for him," Kennedy told the AP, then went on to paraphrase Cuomo in their discussions: "'If it's causing health problems, I really don't want it in New York state. And if it's not causing health problems, we should figure out a way we can do it.'"

Kennedy and two other people close to Cuomo, who spoke to the AP only on condition of anonymity because Cuomo is carefully guarding his discussions on the issue, confirmed the outlines of the plan the governor was considering to allow 10 to 40 test wells in economically depressed southern New York towns that want drilling and the jobs it promises. The plan would allow the wells to operate under intense monitoring by the state to see if fracking should continue or expand.

They all said it was the closest Cuomo has come in his two years in office to making a decision on whether to green-light drilling.

The state has had a moratorium on the process since 2008 while other states in the gas-rich Marcellus Shale formation, such as Pennsylvania, have seen local economies boom as drilling rigs have sprouted up.

Cuomo continues to refuse to talk about his internal process and wouldn't comment for this story. He has been repeating the phrase he's used for two years, that "science, not politics" will rule.

Kennedy, brother of Cuomo's ex-wife, Kerry, described a governor who is intensely involved in the emotion-charged issue, which Cuomo privately likened to taking on the National Rifle Association over gun control laws. Kennedy said Cuomo reached out personally to many others as well in his evaluation.

Kennedy believes Cuomo held off in large part because of the prospect of a new $1 million study by the Geisinger Health System of Pennsylvania, billed by property owners seeking safe fracking and environmentalists as a "large-scale, scientifically rigorous assessment" of drilling in Pennsylvania.

The study will look at detailed health histories of hundreds of thousands of patients who live near wells and other facilities that are producing natural gas from the same Marcellus Shale formation that New York would tap.

Unlike most studies funded by advocates or opponents of hydrofracking, this study would be funded by the Sunbury, Pa.-based Degenstein Foundation, which is not seen as having an ideological bent.

"I think it will be pivotal," Kennedy said. Preliminary results are expected within the year, but there is no specific timetable and final results could be years off. Kennedy is opposed to fracking unless it can be proven to be safe for the environment and public. He said he's unsure what the Geisinger report will conclude.

The Independent Oil and Gas Association of New York, a trade group, didn't immediately respond to a request for comment on Saturday.

Shortly after the conversations with Kennedy in early February, Cuomo's health commissioner, Dr. Nirav Shah, mentioned the Geisinger study among three health reviews still pending and which could enter into Cuomo's decision. Shah, a nationally respected public health figure, was an associate investigator at the Geisinger Center for Health Research before going to work for Cuomo.

Cuomo, a popular Democrat who supporters say may run for president in 2016, is getting criticism from both sides over his delayed decision and calls for more studies. Landowners and industry say they're missing out on an economic boom while environmentalists say the administration should have ordered a full health study and has been too opaque about the regulatory process.

Some pundits have questioned whether Cuomo was "becoming Hamlet on the Shale," echoing a reference to criticism of his father, former Gov. Mario Cuomo, who spent politically damaging months as "Hamlet on the Hudson" publicly debating whether to run for president. It's a characterization Kennedy rejects.

Many federal and state regulators say hydraulic fracturing, which injects a mix of water and chemicals thousands of feet underground to crack open shale and release natural gas, is safe when done properly and thousands of sites have few complaints of pollution. But environmental groups and some doctors say regulations still aren't stringent enough and the practice can pollute ground water. The Marcellus Shale lies under parts of New York, Pennsylvania, Ohio and West Virginia.

"What's interesting is Andrew is trying to figure this out," Kennedy said. "It's interesting to see this ... that usually doesn't happen. (Most governors) take a poll, or they take industry money and just do it ... but I think this is the harder route."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-03-02-US-Gas-Drilling-Cuomo/id-4dea601d4fad47b986175e0a0ed76b3f

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How To Turn Fruits And Vegetables Into a Delicious Musical Instrument

If you wanted to learn an unconventional instrument, maybe you'd opt for the accordion or the glockenspiel. J.viewz decided to build his own. Out of fruits and vegetables. Sure, he didn't have to use fruits and vegetables to create the effect, but it just wouldn't be the same without them. Song's not half bad either. If only all music had this kind of nutritional value. [Vimeo Staff Picks] More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/BIJvj1jB11A/how-to-turn-fruits-and-vegetables-into-a-delicious-musical-instrument

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Adafruit's new Internet of Things Printer goes wireless, uses Raspberry Pi (video)

Adafruit's new Internet of Things Printer goes wireless, uses Raspberry Pi (video)

Adafruit's just outed a new Internet of Things Printer kit that's traded in its ethernet connection for WiFi. Instead of using an Arduino Uno like its wired sibling, the new DIY hardware is built with a Raspberry Pi Model B running Raspbian Linux. Programmed in Python, the software on the box wields the Python Imaging Library, which gives folks flexibility when it comes to typography and graphics, and can leverage the language's raft of libraries. If you're not in the mood for coding, however, the contraption brings a few sample applications that'll print out daily weather reports, sudoku puzzles, tweets and images on 2.25-inch wide receipt paper. The project rings up at $189 -- $100 above its predecessor -- but it isn't up for sale quite yet.

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Source: Adafruit Blog, Adafruit

Source: http://www.engadget.com/2013/03/03/adafruit-internet-of-things-printer-wireless-raspberry-pi/

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Frustrated McIlroy walks off course at Honda

Rory McIlroy, of Northern Ireland, watches his tee shot on the 10th hole during the first round of the Honda Classic golf tournament, Thursday, Feb. 28, 2013, in Palm Beach Gardens, Fla. (AP Photo/Wilfredo Lee)

Rory McIlroy, of Northern Ireland, watches his tee shot on the 10th hole during the first round of the Honda Classic golf tournament, Thursday, Feb. 28, 2013, in Palm Beach Gardens, Fla. (AP Photo/Wilfredo Lee)

(AP) ? Whether his pain was mental or dental, Rory McIlroy walked off the course in the middle of his round Friday at the Honda Classic and invited even more scrutiny of golf's No. 1 player.

McIlroy already was 7-over par through eight holes when he hit his second shot into the water on the par-5 18th and didn't bother hitting another shot. He shook hands with Ernie Els and Mark Wilson, turned in his scorecard and walked straight to the parking lot.

McIlroy told three reporters who followed him that he's "not in a good place mentally."

An hour later, his management company issued a statement that the 23-year-old McIlroy couldn't concentrate because of a sore wisdom tooth.

His abrupt departure only added to the sloppy start to his young season, and raised concerns with the Masters just more than a month away. In three tournaments, he has missed the cut in Abu Dhabi, lost in the first round of the Match Play Championship and withdrew after 26 holes at PGA National.

"His demeanor looks a little different," said Graeme McDowell, one of his best friends. "I felt like he was a little off with his golf swing on the range. There were a few moans and groans coming from the bay next to me. It's normally a display. It's normally a clinic. It's superlatives coming from the coach and the caddie. That's the sign of a guy who's lacking a little technique in his swing and a little belief in his game."

In the parking lot, McIlroy was asked three times if anything was wrong physically and he said no. Golfweek magazine reported he was near tears.

"There's not really much I can say, guys," McIlroy said. "I'm not in a good place mentally, you know?"

Els also hit into the water on the 18th and was complaining to a rules official about the muddy conditions of the fairway when he figured out McIlroy was through.

"I was dropping my ball and I realized he wasn't dropping his ball," Els said. "I thought maybe his ball crossed further up (the hazard). When I hit my fourth shot, he just came up and said, 'Here's my card. I'm out of here.'"

McIlroy, who last year won the Honda Classic to go to No. 1 in the world for the first time, apologized to the tournament for his "sudden withdrawal."

"I have been suffering with a sore wisdom tooth, which is due to come out in the near future," McIlroy said. "It began bothering me again last night, so I relieved it with Advil. It was very painful again this morning, and I was simply unable to concentrate. It was really bothering me and had begun to affect my playing partners."

He was seen eating a sandwich on the 18th fairway.

"I'm a great fan of Rory's, but I don't think that was the right thing to do," Els said.

Told about McIlroy's statement about the sore wisdom tooth, Els softened his stance, not wanting to judge another player's pain.

"I didn't see anything, but if he had a toothache, that's what it is, you know?" Els said. "Hey, it's tough. If you ask him how he's feeling now, he's obviously feeling terrible for what's happened this morning."

"I didn't notice anything," Wilson said. "He wasn't playing the way the world No. 1 plays normally. Didn't hit the ball where he wanted to, and he's a true gentleman, though. He ... wasn't treating Ernie and myself in a different way. He was upset with his golf and I guess he had enough for the week."

Tiger Woods understand better than anyone in golf what it's like to have every move judged, though for Woods it started not long after he turned pro in 1996.

"You've just got to ... think about it a little bit more before you say something or do something," Woods said. " It can get out of hand, especially when you get into social media and start tweeting and all those different things that can go wrong. Jokingly saying something doesn't always come off as saying that, even though the intent was different."

McIlroy, coming off a year in which he won a second major with a record, already set himself up for scrutiny when he left Titleist to sign an equipment deal with Nike that was said to be worth upward of $20 million a year. Instead of taking a long winter break, he spent much of December trying to adjust to his new clubs. McIlroy said Tuesday it wasn't the clubs; his swing was out of sorts.

"I'm sure the guy has got a lot on his mind," McDowell said. "When you start trying to prove things to other people and you stop playing for yourself, it's a dangerous place to be. ... Any player would have did what he's done with regard to the equipment change. He's one of the most talented players I've ever seen. Once he starts believing in himself, he'll be back."

McIlroy won the PGA Championship by a record eight shots last year, making him the youngest player since Seve Ballesteros in 1980 to win two majors. McIlroy won the U.S. Open in 2011 by eight shots with a record score.

Nike introduced him with blaring music and a laser show in Abu Dhabi, but it's been all downhill from there.

After rounds of 75-75 in Abu Dhabi, he took a four-week break and spent time with tennis girlfriend Caroline Wozniacki. He was eliminated at Match Play in a sloppy performance by both of them. McIlroy returned to Florida and played 36 holes with Woods at The Medalist.

He said on Tuesday that it was no time to panic so early in the season.

"Even though my results haven't revealed it, I really felt like I was rounding a corner," McIlroy said. "This is one of my favorite tournaments of the year and I regret having to make the decision to withdraw, but it was one I had to make."

It looked more like McIlroy was sinking than rounding the corner, not difficult to do on a course with so many water hazards. And he found plenty of them.

McIlroy, who opened with a 70, hit two poor chips that led to double bogey on No. 11, and a wild tee shot to the right led to a bogey on the 13th. His round really unraveled on the par-4 16th, when he hit his tee shot to the right and into the water, took a penalty drop and then came up short of the green and into the water again on his way to a triple bogey. He three-putted from 40 feet on the 17th, running his first putt about 10 feet by the hole, for a bogey to go 7 over.

And then came the approach on the 18th that found water for the third time on his short day.

McIlroy is scheduled to play next week in the Cadillac Championship at Doral, which has no cut, and then the Houston Open. But on the first day of March, he left having completed only round of competition.

"I didn't think much of the equipment change. We've all made equipment changes before," said Els, who has used three brands of clubs to win majors. "I think there was a bit of criticism somewhere, and then I think he's further responding to that, and I think he's got a bit of pressure coming on him that way. I thought he played quite well yesterday. I thought he was pretty close to playing good golf, and unfortunately this morning ... hopefully he gets it together. We've got next week, got four rounds there. Such a talented player. He'll get it figured out."

Geoff Ogilvy always preached caution about rushing to judgment of Boy Wonder. A year ago, McIlroy missed the cut in four out of five tournaments, including the U.S. Open. He won four times from August to November, including the PGA and two FedEx Cup playoff events.

"Everyone is being a little hard on the equipment," Ogilvy said. "He has a plan. He had a plan last year, and it all worked out for him. He had a rubbish year, really, until late summer. In May, everyone was throwing him under the bus and everyone was claiming him at the end of the year.

"He'll probably go win the Masters by eight and we'll all go, 'He knew what he was doing.' "

It was the second straight year one of golf's biggest stars failed to finish a tournament on the Florida swing. Woods withdrew after 11 holes on the final round at Doral last year because of tightness in his Achilles tendon, raising questions about the seriousness of his recurring leg injuries. He won Bay Hill two weeks later.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-03-01-GLF-Honda-Classic-McIlroy/id-9c7e2ddada8340118a3392ef9c7d4003

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McConnell readying for tough re-election fight (The Arizona Republic)

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Meet Gladys Stones, Ohio zoo's youngest gorilla

CINCINNATI (AP) ? A baby gorilla that was recently moved to the Cincinnati Zoo from Texas now has a name.

Cincinnati Zoo officials say the female baby gorilla has been named Gladys Stones. That comes from the Gladys Porter Zoo in Brownsville, Texas, where she was born Jan. 29, and from zoo employees Jerry and Cindy Stones there. They cared for the baby at the Texas zoo because her mother displayed a lack of maternal care.

The zoos agreed it was best to relocate the baby to the Cincinnati Zoo, where two female gorillas are available to serve as potential surrogate mothers. Cincinnati Zoo workers over the next few months will help prepare Gladys to join the other gorillas.

Cincinnati Zoo officials said Friday the baby is growing and doing well.

Source: http://news.yahoo.com/meet-gladys-stones-ohio-zoos-youngest-gorilla-192646931.html

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Study shows key enzyme missing from aggressive form of breast cancer

Friday, March 1, 2013

A new study led by the University of Kentucky Markey Cancer Center's Dr. Peter Zhou found that triple-negative breast cancer cells are missing a key enzyme that other cancer cells contain ? providing insight into potential therapeutic targets to treat the aggressive cancer. Zhou's study is unique in that his lab is the only one in the country to specifically study the metabolic process of triple-negative breast cancer cells.

Normally, all cells ? including cancerous cells ? use glucose to initiate the process of making Adenosine-5'-triphosphate (ATP) for fuel to carry out essential functions. This process, called glycolysis, leads to other processes that use oxygen to make higher quantities of ATP ? but solid tumor cells, which have little access to oxygen, are forced to rely almost exclusively on aerobic glycolysis for survival.

Zhou's study, published in Cancer Cell, showed that the powerful transcription factor complex Snail-G9a-Dnmt1 is over-expressed in triple-negative breast cancer, inhibiting the enzyme 1,6-bisphosphate (FBP1). The loss of this enzyme shuts down the glucose anabolic pathway and promotes the glucose catabolic pathway, leading to a large amount of glucose entering the tumor cells and thus "feeding" the aggressive cancer. This metabolic switch empowers the triple-negative breast cancer cells to suck more glucose from the body, increasing macromolecule biosynthesis in tumor cells and maintaining ATP production despite a dearth of nutrients and an oxygen-free environment.

Triple-negative breast cancer is the most deadly subtype of breast cancer, and tends to occur in women at a younger age. This subtype of breast cancer has poor clinical outcomes due to the early metastasis of tumor cells, resistance to chemotherapy, and the lack of specific drugs that target it. Identifying this change in the cancer's metabolic process provides major insight into developing drugs to target the disease, Zhou says.

"These findings present significant insights regarding the development and progression of triple-negative breast cancer," said Zhou, associate professor of molecular and cellular biochemistry at UK. "They indicate that targeting the metabolic alteration will lead to an effective approach for treating this deadly disease."

Zhou's research was aided by the team in the Free Radical Biology in Cancer Shared Resource Facility (FRBC) of the Markey Cancer Center, directed by Dr. Allan Butterfield. The FRBC used an instrument called the Seahorse XF-96 Flux Analyzer to test and confirm the predictions of Zhou's findings in triple-negative breast cancer.

"The significance of this study rests in proving that triple negative breast cancer cells utilize glycolysis for survival and growth," Butterfield said. "The FRBC will assist Dr. Zhou in furthering this exciting research, potentially helping to identify key proteins in triple negative breast cancer cells that are expressed or modified differently than in control cells. Such knowledge may lead to new insights to potential approaches to treat this aggressive cancer."

###

University of Kentucky: http://www.uky.edu

Thanks to University of Kentucky for this article.

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Source: http://www.labspaces.net/127084/Study_shows_key_enzyme_missing_from_aggressive_form_of_breast_cancer

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